| Identification | Back Directory | [Name]
LAS101057 | [CAS]
925676-48-8 | [Synonyms]
LAS101057
LAS-101057,LAS101057
N-[5-(3-fluoropyridin-4-yl)-6-pyridin-3-ylpyrazin-2-yl]cyclopropanecarboxamide
Cyclopropanecarboxamide, N-[5-(3-fluoro-4-pyridinyl)-6-(3-pyridinyl)-2-pyrazinyl]-
N-(5-(3-fluoropyridin-4-yl)-6-(pyridin-3-yl)pyrazin-2-yl)cyclopropanecarboxamide(WXFC0500) | [Molecular Formula]
C18H14FN5O | [MOL File]
925676-48-8.mol | [Molecular Weight]
335.34 |
| Chemical Properties | Back Directory | [Boiling point ]
509.2±50.0 °C(Predicted) | [density ]
1.400±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO:125.0(Max Conc. mg/mL);372.75(Max Conc. mM) | [form ]
A solid | [pka]
11.70±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
LAS 101057 is a potent, selective, and orally efficacious A2B receptor antagonist, was identified as a clinical development candidate. It inhibits agonist-induced IL-6 production in human fibroblasts and is active in an ovalbumin (OVA)-sensitized mouse model after oral administration, reducing airway hyperresponsiveness to methacholine, Th2 cytokine production and OVA-specific IgE levels. |
|
| Company Name: |
Cool Pharm, Ltd
|
| Tel: |
18019463053 |
| Website: |
http://www.coolpharm.com.cn |
|