ChemicalBook--->CAS DataBase List--->926018-45-3

926018-45-3

926018-45-3 Structure

926018-45-3 Structure
IdentificationBack Directory
[Name]

HAEGTFTSD
[CAS]

926018-45-3
[Synonyms]

HAEGTFTSD
[Molecular Formula]

C40H57N11O17
[MDL Number]

MFCD31630837
[MOL File]

926018-45-3.mol
[Molecular Weight]

963.96
Chemical PropertiesBack Directory
[Boiling point ]

1591.6±65.0 °C(Predicted)
[density ]

1.450±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

2.77±0.10(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

HAEGTFTSD is the first N-terminal 1-9 residues of GLP-1 peptide.

The GLP-1 (7-36) amide is a product of the preproglucagon gene, which is secreted from intestinal L-cells, in response to the ingestion of food. GLP-1 exerts multiple actions by stimulating insulin secretion from pancreatic β-cells, in a glucose dependent manner (insulinotropic action). GLP-1 lowers circulating plasma glucagon concentration, by inhibiting its secretion (production) from α-cells. GLP-1 also exhibits properties like stimulation of β-cell growth, appetite suppression, delays gastric emptying and stimulation of insulin sensitivity[1]. The peptide analogs of GLP-1 are useful as glucagon-like peptide 1 receptor agonists[2].

[References]

[1]. US20120264685 [2]. US9738697

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