| Identification | Back Directory | [Name]
GSK 461364 analogue I | [CAS]
929095-23-8 | [Synonyms]
GSK579289A
GSK 461364 analogue I | [Molecular Formula]
C26H27ClN4O3S | [MDL Number]
MFCD18089836 | [MOL File]
929095-23-8.mol | [Molecular Weight]
511.04 |
| Hazard Information | Back Directory | [Biological Activity]
GSK579289A is an inhibitor of polo-like kinase 1 (Plk1; IC50 = 2 nM).1 It is selective for Plk1 over Plk3 (IC50 = 630 nM). GSK579289A inhibits proliferation of HCT116 cells (IC50 = 11 nM). | [storage]
-20°C | [References]
1.Rheault, T.R., Donaldson, K.H., Badiang-Alberti, J.G., et al.Heteroaryl-linked 5-(1H-benzimidazol-1-yl)-2-thiophenecarboxamides: Potent inhibitors of polo-like kinase 1 (PLK1) with improved drug-like propertiesBioorg. Med. Chem. Lett.20(15)4587-4592(2010)
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| Company Name: |
BOC Sciences
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https://www.bocsci.com |
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