| Identification | Back Directory | [Name]
Benzeneacetic acid, 3-[[[3-(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)propyl][3-(dimethylamino)propyl]amino]methyl]-, methyl ester | [CAS]
929551-91-7 | [Synonyms]
AZ12441970
AZ-12441970
AZ 12441970
Benzeneacetic acid, 3-[[[3-(6-amino-2-butoxy-7,8-dihydro-8-oxo-9H-purin-9-yl)propyl][3-(dimethylamino)propyl]amino]methyl]-, methyl ester | [Molecular Formula]
C27H41N7O4 | [MOL File]
929551-91-7.mol | [Molecular Weight]
527.66 |
| Hazard Information | Back Directory | [Description]
AZ12441970 is a potent toll-like receptor 7 agonist (TLR7 agonist). AZ12441970 showed efficacy in a mouse allergic airway model with minimal induction of systemic IFN-α, consistent with the low plasma levels of compound. AZ12441970 induced high levels of the notch ligands Dll1 and Dll4 mRNA, whereas immobilized DLL4 resulted in the suppression of IL-5 production. |
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