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934389-88-5

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934389-88-5 Structure

934389-88-5 Structure
IdentificationBack Directory
[Name]

LY 294002
[CAS]

934389-88-5
[Synonyms]

LY 294002, HYDROCHLORIDE SALT
LY 294002, Hydrochloride Salt, >99%
LY-294,002 hydrochloride, ≥98% (HPLC)
LY-294,002 hydrochloride, 98%, selective inhibitor of PI 3-kinase
[Molecular Formula]

C19H18ClNO3
[MDL Number]

MFCD01530034
[MOL File]

934389-88-5.mol
[Molecular Weight]

343.804
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

DMSO: >5mg/mL
[form ]

solid
[color ]

white to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P271-P280
[WGK Germany ]

3
[HS Code ]

29349990
Hazard InformationBack Directory
[Uses]

LY 294002 Hydrochloride is a highly selective inhibitor of Phosphatidylinositol 3-kinase (PI3K). It is a salt analogue of LY 294002 (L486590).
[General Description]

LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K). LY-294,002 inhibits nuclear factor kappa B signaling in macrophages. It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric and nasopharyngeal cancer cells. LY-294,002 modulates action potential repolarization and improves myocyte contractility.
[storage]

Room temperature
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