| Identification | Back Directory | [Name]
Urea, N-(3-nitrophenyl)-N'-(4-phenyl-2-thiazolyl)- | [CAS]
941521-45-5 | [Synonyms]
BAZ1A-IN-1
Urea, N-(3-nitrophenyl)-N'-(4-phenyl-2-thiazolyl)- | [Molecular Formula]
C16H12N4O3S | [MOL File]
941521-45-5.mol | [Molecular Weight]
340.36 |
| Chemical Properties | Back Directory | [density ]
1.481±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 83.33 mg/mL (244.83 mM; Need ultrasonic) | [form ]
Solid | [pka]
5.83±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Biological Activity]
BAZ1A-IN-1 is a potent inhibitor of BAZ1A (bromodomain-containing protein). BAZ1A-IN-1 shows a KD value of 0.52 μM against BAZ1A bromodomain. BAZ1A-IN-1 shows good anti-viability activity against cancer cell lines expressing a high level of BAZ1A, but weak or no activity against cancer cells with a low expression level of BAZ1A[1].
BAZ1A-IN-1 (Cpd-2) (0.015-100 μM; 96 hours) exhibits good anti-viability activity against all the four cancer cell lines that have a high expression level of BAZ1A, with IC50 values of 5.08 μM, 4.29 μM, 10.65 μM, and 7.70 μM for THP-1, ZR-75-30, BT474, and H1975 cells, respectively[1]. | [References]
[1]. Yang Z, et al. Discovery of BAZ1A bromodomain inhibitors with the aid of virtual screening and activity evaluation. Bioorg Med Chem Lett. 2021;33:127745. |
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