| Identification | Back Directory | [Name]
PI 828 | [CAS]
942289-87-4 | [Synonyms]
PI 828
LY 294002, 4′-NH2
LY 294002, 4-NH - CAS 942289-87-4 - Calbiochem
8-(4-aminophenyl)-2-morpholin-4-ylchromen-4-one
2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one
8-(4-Aminophenyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one | [Molecular Formula]
C19H18N2O3 | [MDL Number]
MFCD11100185 | [MOL File]
942289-87-4.mol | [Molecular Weight]
322.36 |
| Chemical Properties | Back Directory | [Boiling point ]
534.2±50.0 °C(Predicted) | [density ]
1.316±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: slightly soluble | [form ]
Off-white solid | [pka]
4.14±0.10(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Definition]
ChEBI: 8-(4-aminophenyl)-2-(4-morpholinyl)-1-benzopyran-4-one is a member of chromones. | [General Description]
A cell-permeable LY 294002 (Cat. Nos. 440202 & 440204) 4′-amino derivative with enhanced potency against p110α/β/δ/γ (IC50 in nM/-fold increase in potency = 183/2.7-, 98/5.7-, 1227/.5-, and 1967/1.9-, respectively). The molecule has been immobilized on epoxy-containing solid surface via the 4′-amine for binding studies and shown to interact with non-PI3K cellular proteins, such as mTOR, ALDH1, Brd4, GSK3β, and CKIIα. | [Biological Activity]
PI 3-Kinase inhibitor (IC 50 values are 0.098, 0.183, 0.227 and 1.967 μ M for p110 β , p110 α , p110 δ and p110 γ respectively) that displays higher potency than LY 294002 (2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride). Can be immobilized onto a solid phase. | [storage]
Store at +4°C |
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BOC Sciences
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https://www.bocsci.com |
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