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ChemicalBook--->CAS DataBase List--->946293-78-3

946293-78-3

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946293-78-3 Structure

946293-78-3 Structure
IdentificationBack Directory
[Name]

Aumitin
[CAS]

946293-78-3
[Synonyms]

Aumitin
[Molecular Formula]

C24H20ClN5O
[MDL Number]

MFCD09238311
[MOL File]

946293-78-3.mol
[Molecular Weight]

429.9
Chemical PropertiesBack Directory
[density ]

1.364±0.06 g/cm3(Predicted)
[form ]

Solid
[pka]

12.36±0.70(Predicted)
[color ]

White to off-white
Spectrum DetailBack Directory
[Spectrum Detail]

Aumitin(946293-78-3)1HNMR
Hazard InformationBack Directory
[Biological Activity]

Aumitin is a diaminopyrimidine-based autophagy inhibitor which inhibits mitochondrial respiration by targeting complex I. Aumitin inhibits starvation- and rapamycin induced autophagy dose dependently with IC50s of 0.12 μM and 0.24 μM, respectively[1].
[References]

[1]. Robke L, et al. Discovery of the novel autophagy inhibitor aumitin that targets mitochondrial complex I. Chem Sci. 2018 Feb 26;9(11):3014-3022.
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