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U-46619 is the consensus stable analog of prostaglandin H2/thromboxane A2 (PGH2/TXA2) and has been used as a TXA2 agonist in pharmacologic studies for several decades.1 There have been several hypotheses put forward by scientists studying ω-3 fatty acids stipulating that the agonist activity of TXA3 was substantially different than that of TXA2.2 However, no stable analogs of TXA3 were available to test these theories. Δ17-U-46619 is the first direct, stable analog of TXA3 ever synthesized. There are no published reports on its activity to date. | [References]
1. Bundy, G.L. The synthesis of prostaglandin endoperoxide analogs Tetrahedron Lett. 24,1957-1960(1975).
2. Parent, C.A., Lagarde, M., Venton, D.L., et al. Selective modulation of the human platelet thromboxane A2/prostaglandin H2 receptor by eicosapentaenoic and docosahexaenoic acids in intact platelets and solubilized platelet membranes J. Biol. Chem. 267,6541-6547(1992). |
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