ChemicalBook--->CAS DataBase List--->947620-48-6

947620-48-6

947620-48-6 Structure

947620-48-6 Structure
IdentificationBack Directory
[Name]

E6005
[CAS]

947620-48-6
[Synonyms]

E6005
RVT-501
CS-2517
lotamilast
E 6005;E-6005
RVT-501 E6005
E 6005: RVT-501
METHYL 4-((3-(6,7-DIMETHOXY-2-(METHYLAMINO)QUINAZOLIN-4-YL)PHENYL)CARBAMOYL)BENZOATE
methyl 4-[({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}amino)carbonyl]benzoate
Benzoic acid, 4-[[[3-[6,7-dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]amino]carbonyl]-, methyl ester
[Molecular Formula]

C26H24N4O5
[MDL Number]

MFCD28502071
[MOL File]

947620-48-6.mol
[Molecular Weight]

472.49
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

DMSO:25.0(Max Conc. mg/mL);52.9(Max Conc. mM)
[form ]

A solid
[color ]

Light yellow to yellow
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
Hazard InformationBack Directory
[Description]

E6005 is an inhibitor of phosphodiesterase 4 (PDE4; IC50 = 2.8 nM). It is selective for PDE4 over PDE1, PDE2, PDE3, and PDE5 with only 46.1, 51.6, 69.4, and 57.4% inhibition, respectively, at 30 μM. It inhibits the production of various cytokines in isolated human lymphocytes and monocytes (IC50s = 0.49-3.1 nM). Topical application of E6005 (0.003-0.3%) reduces ear thickness in a mouse model of oxazolone-induced skin inflammation, as well as reduces oxazolone-induced scratching in mice. It reduces the severity of skin lesions in a model of mite-induced atopic dermatitis. Topical application of E6005 (0.03%) also inhibits the production of leukotriene B4 (LTB4; Item No. 20110) in mouse skin, as well as reduces scratching and cutaneous nerve firing induced by the proteinase-activated receptor 2 (PAR2) agonist SLIGRL-NH2 (Item No. 16723) in mice.
[Uses]

RVT 501 is a potent and selective inhibitor of human phosphodiesterase 4 (PDE4).
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