Identification | Back Directory | [Name]
E6005 | [CAS]
947620-48-6 | [Synonyms]
E6005 RVT-501 CS-2517 lotamilast E 6005;E-6005 RVT-501 E6005 E 6005: RVT-501 METHYL 4-((3-(6,7-DIMETHOXY-2-(METHYLAMINO)QUINAZOLIN-4-YL)PHENYL)CARBAMOYL)BENZOATE methyl 4-[({3-[6,7-dimethoxy-2-(methylamino)quinazolin-4-yl]phenyl}amino)carbonyl]benzoate Benzoic acid, 4-[[[3-[6,7-dimethoxy-2-(methylamino)-4-quinazolinyl]phenyl]amino]carbonyl]-, methyl ester | [Molecular Formula]
C26H24N4O5 | [MDL Number]
MFCD28502071 | [MOL File]
947620-48-6.mol | [Molecular Weight]
472.49 |
Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:25.0(Max Conc. mg/mL);52.9(Max Conc. mM) | [form ]
A solid | [color ]
Light yellow to yellow |
Hazard Information | Back Directory | [Description]
E6005 is an inhibitor of phosphodiesterase 4 (PDE4; IC50 = 2.8 nM).1 It is selective for PDE4 over PDE1, PDE2, PDE3, and PDE5 with only 46.1, 51.6, 69.4, and 57.4% inhibition, respectively, at 30 μM. It inhibits the production of various cytokines in isolated human lymphocytes and monocytes (IC50s = 0.49-3.1 nM). Topical application of E6005 (0.003-0.3%) reduces ear thickness in a mouse model of oxazolone-induced skin inflammation, as well as reduces oxazolone-induced scratching in mice. It reduces the severity of skin lesions in a model of mite-induced atopic dermatitis. Topical application of E6005 (0.03%) also inhibits the production of leukotriene B4 (LTB4; Item No. 20110) in mouse skin, as well as reduces scratching and cutaneous nerve firing induced by the proteinase-activated receptor 2 (PAR2) agonist SLIGRL-NH2 (Item No. 16723) in mice.2 | [Uses]
RVT 501 is a potent and selective inhibitor of human phosphodiesterase 4 (PDE4). |
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Company Name: |
BOC Sciences
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Tel: |
1-631-485-4226; 16314854226 |
Website: |
https://www.bocsci.com |
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