| Identification | Back Directory | [Name]
(25S)-Δ7-Dafachronic Acid | [CAS]
949004-12-0 | [Synonyms]
(25S)-Δ7-Dafachronic Acid
(25S)-Delta(7)-dafachronic acid
Cholest-7-en-26-oic acid, 3-oxo-, (5α,25S)-
(25S)-delta-7-Dafachronic acid,(25S) delta7 Dafachronic acid,(25S)delta7Dafachronic acid
(2S,6R)-6-[(5S,9R,10S,13R,14R,17R)-10,13-dimethyl-3-oxo-1,2,4,5,6,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-methylheptanoic acid | [Molecular Formula]
C27H42O3 | [MOL File]
949004-12-0.mol | [Molecular Weight]
414.62 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 5 mg/ml; DMSO: 2.5 mg/ml; Ethanol: 12.5 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
During unfavorable environmental conditions, C. elegans larvae undergo arrest and form dauer larvae that can attach to other animals as a parasitic strategy for survival. DAF-12 is an orphan nuclear hormone receptor that regulates dauer larva diapause, reproductive development, fat metabolism, and life cycle/longevity in C. elegans. DAF-12 is required for entry into dauer when it is not bound to ligand by acting as a transcriptional repressor of target genes that favor reproductive development. (25S)-Δ7-Dafachronic acid is a sterol-derived hormone that acts as a ligand of DAF-12 with an EC50 value of 23 nM. At 50 nM, (25S)-Δ7-Dafachronic acid inhibits the dauer-promoting activity of DAF-12, blocking the formation of infective larvae in several parasitic nematodes in favor of reproductive maturation to adults. Thus, selective ligand modulators of DAF-12 are a potential therapeutic approach to stop larvae progression during parasitic infection. | [Definition]
ChEBI: A Delta7-dafachronic acid that has S configuration at position 25 (the carbon attached to the carboxy group). | [storage]
+4°C |
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