| Identification | Back Directory | [Name]
3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine | [CAS]
952143-02-1 | [Synonyms]
3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine
3H-Diazirine, 3-(4-bromophenyl)-3-(trifluoromethyl)- | [Molecular Formula]
C8H4BrF3N2 | [MOL File]
952143-02-1.mol | [Molecular Weight]
265.03 |
| Hazard Information | Back Directory | [Uses]
3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine is a Suzuki-Miyaura (S?M)-compatible building block tailored for the design of photoaffinity probes (PAPs). Photoaffinity labeling (PAL) is of growing interest in chemical biology and drug discovery research for use in protein profiling; covalent inhibitors; protein-protein interactions and complexes; and target engagement, identification, or validation studies. Diazirines are desirable photoactivable groups for chemical probes; however, their installation is not always straightforward. In response, diazirine-tolerant S-M coupling conditions were developed by Ichiishi, et al, using 3-(4-bromophenyl)-3-(trifluoromethyl)-3H-diazirine and shown to be efficient and scalable with minimal perturbation of the diazirine. | [reaction suitability]
reagent type: cross-linking reagent |
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