| Identification | Back Directory | [Name]
PF 477736 (HCl) | [CAS]
952238-93-6 | [Synonyms]
PF 477736 (HCl)
(alphaR)-alpha-Amino-N-[5,6-dihydro-2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-1H-pyrrolo[4,3,2-ef][2,3]benzodiazepin-8-yl]cyclohexaneacetamide hydrochloride | [Molecular Formula]
C22H26ClN7O2 | [MDL Number]
MFCD16038846 | [MOL File]
952238-93-6.mol | [Molecular Weight]
455.95 |
| Hazard Information | Back Directory | [Definition]
ChEBI: PF-00477736 is a diazepinoindole that is 8-amino-4,5-dihydro-6H-[1,2]diazepino[4,5,6-cd]indol-6-one which is substituted at position 2 by a 1-methylpyrazol-4-yl group and in which the amino group at position 8 has undergone condensation with the carboxy group of (2R)-2-cyclohexylglycine to give the corresponding carboxamide. It is an inhibitor of checkpoint kinase 1 (Chk 1). It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor and an antineoplastic agent. It is an amino acid amide, a member of pyrazoles and a diazepinoindole. |
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