| Identification | Back Directory | [Name]
Brequinar | [CAS]
96187-53-0 | [Synonyms]
BPQ
CS-157
Brequinar
Biphenquinate
Brequinar (DUP785)
BREQUINAR;BIPENQUINATE;DUP 785;NSC 368390.
6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)
6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-Methylquinoline-4-carboxyl
6-fluoro-2-(2'-fluorobiphenyl-4-yl)-3-methylquinoline-4-carboxylic acid
6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid
6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid
6-Fluoro-2-(2'-fluoro-[1,1'-biphenyl]-4-yl)-3-methylquinoline-4-carboxylic acid
4-Quinolinecarboxylic acid, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-Methyl- | [Molecular Formula]
C22H13F2NO2 | [MDL Number]
MFCD00866437 | [MOL File]
96187-53-0.mol | [Molecular Weight]
375.37 |
| Chemical Properties | Back Directory | [Melting point ]
355-357℃ (N,N-dimethylformamide water ) | [storage temp. ]
2-8°C | [solubility ]
DMSO:25.9(Max Conc. mg/mL);70.0(Max Conc. mM) | [form ]
powder to crystal | [pka]
pKa 4.45(H2O t=RT I=0.10) (Uncertain) | [color ]
White to Light yellow | [CAS DataBase Reference]
96187-53-0 |
| Hazard Information | Back Directory | [Uses]
Antineoplastic. | [Definition]
ChEBI:Brequinar is a quinolinemonocarboxylic acid that is quinoline substituted by 2'-fluoro[1,1'-biphenyl]-4-yl, methyl, carboxy and fluoro groups at positions 2, 3, 4, and 6, respectively. It is an inhibitor of dihydroorotate dehydrogenase, an enzyme that is required for de novo pyrimidine biosynthesis. The compound exhibits antineoplastic and antiviral properties. It has a role as an EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor, an immunosuppressive agent, an antineoplastic agent, an antiviral agent, a pyrimidine synthesis inhibitor, an anticoronaviral agent and an antimetabolite. It is a member of biphenyls, a member of monofluorobenzenes, a quinolinemonocarboxylic acid and a monocarboxylic acid. It is a conjugate acid of a brequinar(1-). | [storage]
Store at -20°C |
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