| Identification | Back Directory | [Name]
15(R)-15-METHYL PROSTAGLANDIN A2 | [CAS]
96440-68-5 | [Synonyms]
Reaxys ID: 3005095
UEBXYYKXJUBAJX-ULDSDQABSA-N
15(R)-15-METHYL PROSTAGLANDIN A2
9-Oxo-15R-hydroxy-15-hethyl-prosta-5Z,10,13E-trien-1-oic acid
9-OXO-15R-HYDROXY-15-METHYL-PROSTA-5Z,10,13E-TRIEN-1-OIC ACID | [Molecular Formula]
C21H32O4 | [MDL Number]
MFCD00216038 | [MOL File]
96440-68-5.mol | [Molecular Weight]
348.48 |
| Chemical Properties | Back Directory | [solubility ]
DMF: >75 mg/ml (from PGA1); DMSO: >50 mg/ml (from PGA1); Ethanol: >100 mg/ml (from PGA1); PBS pH 7.2: >2.4 mg/ml (from PGA1) |
| Hazard Information | Back Directory | [Description]
Arbaprostil (15(R)-15-methyl prostaglandin E2) is a synthetic prostaglandin E2 (PGE2) analog developed for its cytoprotective activity.1 15(R)-15-methyl Prostaglandin A2 (15(R)-15-methyl PGA2) is one of several impurities which are possible in the production of commercial lots of bulk arbaprostil.2 The pharmacology and EP receptor binding affinity for 15(R)-15-methyl PGA2 has not been published. | [Definition]
ChEBI: 15(R)-15-methyl Prostaglandin A2 is a prostanoid. | [References]
1. Collins, P.W. Misoprostol: Discovery, development, and clinical applications Med. Res. Rev. 10(2),149-172(1990).
2. Kissinger, L.D., and Robins, R.H. Silver-modified mobile phase for normal-phase liquid chromatographic determination of prostaglandins and their 5,6-trans isomers in prostaglandin bulk drugs and triacetin solutions J. Chromatogr. 321(2),353-362(1985). |
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