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96750-66-2

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96750-66-2 Structure

96750-66-2 Structure
IdentificationBack Directory
[Name]

CHLORISONDAMINE DIIODIDE
[CAS]

96750-66-2
[Synonyms]

Chlorisondamine (iodide)
4,5,6,7-tetrachloro-2-methyl-2-[2-(trimethylammonium)ethyl]isoindolinium diiodide
[Molecular Formula]

C14Cl4H20I2N2
[MDL Number]

MFCD01074794
[MOL File]

96750-66-2.mol
[Molecular Weight]

611.94
Chemical PropertiesBack Directory
[storage temp. ]

2-8°C
[solubility ]

H2O: ~3.75 mg/mL
[form ]

solid
[color ]

white
[Water Solubility ]

Soluble to 10 mM in water
Safety DataBack Directory
[Hazard Codes ]

Xn,N
[Risk Statements ]

22-50
[Safety Statements ]

60-61
[RIDADR ]

UN 3077 9 / PGIII
[WGK Germany ]

2
Hazard InformationBack Directory
[Description]

Chlorisondamine is an antagonist of nicotinic acetylcholine receptors (nAChRs; IC50 = 1.8 μM in rat striatal synaptosomes) and a ganglion blocker. It decreases dopamine release induced by nicotine (Item Nos. 16535 | 20887) in a dose-dependent manner in rat striatal synaptosomes at concentrations ranging from 0-100 μM. The effect of chlorisondamine is long-lasting, with a 10 mg/kg dose blocking nicotine-induced stimulant activity for at least five weeks. Chlorisondamine (5 μg, i.c.v.) prevents rats from acquiring a (–)-nicotine-induced conditioned taste aversion response, a model of the aversive effects of nicotine. It also inhibits autonomic ganglia, providing approximately 50% inhibition of the contractile response in feline superior cervical ganglion nictitating membrane preparations when administered at a dose of 50 mg/kg.
[Uses]

Chlorisondamine diiodide has been used:
  • as a nicotinic receptor antagonist to test its effect on trinitrobenzene sulfonic acid (TNBS)-induced colitis
  • as an irreversible nicotinic acetylcholine(nAChR) blocker to pre-treat brain samples to test its effect on cytochrome P450 2B (CYP2B) induction
  • as a ganglionic blocker to test its effect on regulating corticosterone levels in rat with chronic stress

[Biochem/physiol Actions]

Chlorisondamine diiodide mediates ganglionic and central blockade.
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