| Identification | Back Directory | [Name]
(2S)-5,7-Dihydroxy-2,3-dihydro-2α-(2-methoxy-4-hydroxyphenyl)-8-[(R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one | [CAS]
97938-31-3 | [Synonyms]
Leachiane A
(-)-Vexibidin
Leachianone A
2'-methoxy-5,7,4'-trihydroxy-8-lavandulylflavanone
(S)-5,7-Dihydroxy-2-(4-hydroxy-2-Methoxyphenyl)-8-((R)-5-Methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl)chroMan-4-one
(2S)-5,7-Dihydroxy-2,3-dihydro-2α-(2-methoxy-4-hydroxyphenyl)-8-[(R)-5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxy-2-methoxyphenyl)-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-, (2S)- | [Molecular Formula]
C26H30O6 | [MDL Number]
MFCD20260442 | [MOL File]
97938-31-3.mol | [Molecular Weight]
438.51 |
| Chemical Properties | Back Directory | [Boiling point ]
649.7±55.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
7.67±0.40(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
Leachianone A is a phenolic compound isolated from Sophora flavescens Soland with potential anti-malarial and anti-inflammatory properties. | [Definition]
ChEBI: Leachianone A is a trihydroxyflavanone that is (2S)-flavanone substituted by a lavandulyl group at position 8, hydroxy groups at positions 5, 7 and 4' and a methoxy group at position 2'. Isolated from the roots of Sophora flavescens and Sophora leachiana, it exhibits antineoplastic and antimalarial activity. It has a role as a metabolite, an antineoplastic agent and an antimalarial. It is a monomethoxyflavanone, a trihydroxyflavanone and a member of 4'-hydroxyflavanones. It is functionally related to a (2S)-flavanone. | [in vivo]
Leachianone A (intravenously injection; 20 mg/kg, 30 mg/kg; once daily; 30 days) significantly diminishes the tumor volume by 17-54% in LA-treated nude mice, when compared with those solely given the vehicle[1]. | Animal Model: | Male nude mice with human hepatoma HepG2 cells[1] | | Dosage: | 20 mg/kg; 30 mg/kg | | Administration: | Intravenously injection; 20 mg/kg, 30 mg/kg; once daily; 30 days | | Result: | Suppressed the tumor growth in vivo. |
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