ChemicalBook--->CAS DataBase List--->99011-78-6

99011-78-6

99011-78-6 Structure

99011-78-6 Structure
IdentificationBack Directory
[Name]

IMiquiMod (hydrochloride)
[CAS]

99011-78-6
[Synonyms]

IMiquiMod (hydrochloride)
Imiquimod hydrochloride (R 837 hydrochloride)
[Molecular Formula]

C14H17ClN4
[MDL Number]

MFCD28168057
[MOL File]

99011-78-6.mol
[Molecular Weight]

276.765
Chemical PropertiesBack Directory
[Melting point ]

>300 °C
[storage temp. ]

Keep in dark place,Sealed in dry,Room Temperature
[solubility ]

≥3.59 mg/mL in EtOH with ultrasonic; ≥5.54 mg/mL in DMSO with gentle warming and ultrasonic; ≥7.34 mg/mL in H2O with ultrasonic
[form ]

solid
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Spectrum DetailBack Directory
[Spectrum Detail]

IMiquiMod (hydrochloride)(99011-78-6)1HNMR
Hazard InformationBack Directory
[Biological Activity]

imiquimod hydrochloride is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas.
[in vivo]

In animal models, Imiquimod hydrochloride stimulates the innate immune response by increasing NK cell activity, activating macrophages to secretecytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod hydrochloride stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumor necrosis factor (TNF)-α.

[target]

TLR7

HSV-1

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