| Identification | Back Directory | [Name]
L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI) | [CAS]
99141-91-0 | [Synonyms]
Ac-Ala-Val-OMe
L-Valine, N-acetyl-L-alanyl-, methyl ester (9CI) | [Molecular Formula]
C11H20N2O4 | [MOL File]
99141-91-0.mol | [Molecular Weight]
244.29 |
| Chemical Properties | Back Directory | [Melting point ]
105 °C | [Boiling point ]
442.1±25.0 °C(Predicted) | [density ]
1.078±0.06 g/cm3(Predicted) | [storage temp. ]
-10 to -25°C | [solubility ]
Soluble to 100 mM in ethanol and to 100 mM in DMSO | [form ]
Oil | [pka]
13.30±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Biological Activity]
ZZL-7 is a fast-acting antidepressant that enhances 5-HT (serotonin) signaling in forebrain circuits. ZZL-7 disrupts the interaction between the 5-HT transporter (SERT) and neuronal nitric oxide synthase (nNOS) in the dorsal raphe nucleus (DRN), which reduces extracellular 5-HT concentration and down-regulates 5-HT1A receptor auto-activity in the DRN. This reduced auto-inhibition enables increase in firing frequency of serotonergic neurons in the DRN and increases in 5-HT release in the medial hippocampus. ZZL-7 can readily cross the blood-brain barrier. | [storage]
Store at -20°C |
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| Company Name: |
R&D Systems, Inc
|
| Tel: |
18003437475 18003437475 |
| Website: |
www.rndsystems.com |
| Company Name: |
Merck KGaA
|
| Tel: |
(+86) 21 2033 8288 |
| Website: |
http://www.sigmaaldrich.cn |
|