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10030-78-1

中文名称 6-羟基-2-氨甲基嘌呤
英文名称 6-HYDROXY-2-METHYLAMINOPURINE
CAS 10030-78-1
分子式 C6H7N5O
分子量 165.15
MOL 文件 10030-78-1.mol
10030-78-1 结构式 10030-78-1 结构式

基本信息

中文别名
N2-甲基鸟嘌呤
2-甲氨基-6-羟基嘌呤
6-羟基-2-氨甲基嘌呤
6-羟基-2-氨甲基嘌呤 10G
2-(甲基氨基)-1H-嘌呤-6(7H)-酮
2-(甲基氨基)-6,7-二氢-3H-嘌呤-6-酮
英文别名
N2-METHYLGUANINE
2-(MethylaMino)-7H-purin-6-ol
6-HYDROXY-2-METHYLAMINOPURINE
2-(MethylaMino)-1H-purin-6(7H)-one
2-methylamino-3,7-dihydropurin-6-one
1,7-Dihydro-2-(methylamino)-6H-purin-6-one
2-(methylamino)-6,7-dihydro-3H-purin-6-one
6H-Purin-6-one,1,9-dihydro-2-(methylamino)-
Endogenous Metabolite,Inhibitor,Bacterial,2 (Methylamino) 1H purin 6(7H) one,2(Methylamino)1Hpurin6(7H)one,inhibit,DNA/RNA Synthesis

物理化学性质

熔点>300 °C (decomp)
密度1.79±0.1 g/cm3(Predicted)
储存条件4°C, Inert atmosphere
溶解度DMSO : < 1 mg/mL (insoluble or slightly soluble)
酸度系数(pKa)9.86±0.20(Predicted)
形态Solid
颜色Light yellow to khaki
6-羟基-2-氨甲基嘌呤价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/04/30HY-1014126-羟基-2-氨甲基嘌呤
2-(Methylamino)-1H-purin-6(7H)-one
10030-78-15mg1500元
2024/04/30HY-1014126-羟基-2-氨甲基嘌呤
2-(Methylamino)-1H-purin-6(7H)-one
10030-78-110mg2400元
2024/04/30HY-1014126-羟基-2-氨甲基嘌呤
2-(Methylamino)-1H-purin-6(7H)-one
10030-78-150mg7500元

常见问题列表

生物活性
2-(Methylamino)-1H-purin-6(7H)-one (N2-Methylguanine) 是经过修饰的核苷,是在人体液中存在的内源性甲基化核苷。
靶点

Human Endogenous Metabolite

体外研究

2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) is found within both helical and looped regions of RNA secondary structure, and it can exist in either the s-cis or the s-trans rotamer. If there is a rotational preference for the methyl group, the effect of 2-(Methylamino)-1H-purin-6(7H)-one substitution may be specific to the sequence context depending upon which face of the base participates in hydrogen bonding. 2-(Methylamino)-1H-purin-6(7H)-one (N2-methylguanine) is the principal kinetic barrier for reverse transcription in the 1340 bases proximal to the 5' end of E. coli 16S rRNA. Transcription intermediates correspond to attenuation at the positions of 2-(Methylamino)-1H-purin-6(7H)-one in the rRNA sequence. The relaxation time for elongation of the cDNA through m2G is approximately 3 min.

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