101189-47-3
中文名称
101189-47-3
英文名称
2-(N-Pentyl-N'-guanidino)-4-(2-methylimidazol-4-yl)thiazole
CAS
101189-47-3
分子式
C13H20N6S
分子量
292.4
MOL 文件
101189-47-3.mol
101189-47-3 结构式
基本信息
中文别名
化合物 T15005 英文别名
CP-66,9482-(N-Pentyl-N'-guanidino)-4-(2-methylimidazol-4-yl)thiazole
Guanidine, N-[4-(2-methyl-1H-imidazol-5-yl)-2-thiazolyl]-N'-pentyl-
1-[4-(2-methyl-1H-imidazol-5-yl)-1,3-thiazol-2-yl]-2-pentylguanidine
物理化学性质
沸点517.0±42.0 °C(Predicted)
密度1.34±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)11.38±0.10(Predicted)
常见问题列表
生物活性
CP-66948 是 histamine H2 受体拮抗剂,能够抑制胃酸分泌,保护粘膜的作用。体内研究
The affinity of CP-66,948 for the guinea pig atria histamine H2-receptor is 15 times greater than that of cimetidine and seven times greater than that of ranitidine. In vivo, the ED 50 value for inhibition of gastric acid secretion in pylorus-ligated rats is 2 mg/kg intraduodenally, and in histamine or pentagastrin-stimulated Heidenhain pouch dogs the antisecretory ED 50 values are 0.3 mg/kg per os and 1.0 mg/kg per os, respectively. CP-66,948 also inhibits ethanol-induced gastric hemorrhagic lesions in rats following either oral or systemic administration (ED 50 values of 12 mg/kg per os and 6 mg/kg subcutaneously).