101387-97-7

中文名称 101387-97-7

英文名称 5,7-Dihydro-2-[(4-methoxy-3-methyl-2-pyridinyl)methylthio]-5,5,7,7-tetramethylindeno[5,6-d]imidazol-6(1H)-one

CAS 101387-97-7

分子式 C22H25N3O2S

分子量 395.52

MOL 文件 101387-97-7.mol

101387-97-7 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

化合物 T19549

英文别名

Ro-18-5362
5,7-Dihydro-2-[(4-methoxy-3-methyl-2-pyridinyl)methylthio]-5,5,7,7-tetramethylindeno[5,6-d]imidazol-6(1H)-one
Indeno[5,6-d]imidazol-6(1H)-one, 5,7-dihydro-2-[[(4-methoxy-3-methyl-2-pyridinyl)methyl]thio]-5,5,7,7-tetramethyl-

物理化学性质

沸点593.4±60.0 °C(Predicted)

密度1.27±0.1 g/cm3(Predicted)

储存条件-20°C储存

溶解度溶于二甲基亚砜

酸度系数(pKa)10.28±0.60(Predicted)

常见问题列表

生物活性

Ro18-5362 是一种活性较低的 Ro 18-5364 前体。即使在浓度高达 0.1 mM 下，Ro 18-5362 也不能显着影响 H++K+-ATPase 活性。

体外研究

Marked differences are seen between Ro 18-5364 (sulfoxide) and Ro18-5362 (sulfide) with regard to inhibitory activity. Even at concentrations as high as 0.1 mM Ro18-5362 fails to affect significantly (H ⁺ +K ⁺ )-ATPase activity and associated proton translocation. The sulfoxide Ro 18-5364, a potential metabolite of the IND Ro18-5362, is a powerful inhibitor of gastric mucosal (H ⁺ +K ⁺ )-ATPase, decreasing enzymatic activity with an apparent K _i of 0.1 μM.