1018332-24-5
中文名称
(2R,4R-4-(((9H-FLUO
英文名称
(2R,4R)-4-(((9H-fluoren-9-yl)Methoxy)carbonylaMino)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid
CAS
1018332-24-5
分子式
C25H28N2O6
分子量
452.5
MOL 文件
1018332-24-5.mol
1018332-24-5 结构式
基本信息
中文别名
N-BOC-顺式-4-N-FMOC-氨基-D-脯氨酸(2R,4R)-4-((((9H-芴-9-基)甲氧基)羰基)氨基)-1-(叔丁氧基羰基)吡咯烷-2-羧酸
英文别名
(2R,4R-4-(((9H-FLUON-Boc-cis-4-N-Fmoc-amino-D-proline
(4R)-1-Boc-4-(Fmoc-amino)-D-proline
(4R)-4-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-1-{[(2-methyl-2- propanyl)oxy]carbonyl}-D-proline
(2R,4R)-1-[(tert-butoxy)carbonyl]-4-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)pyrrolidine-2-carboxylic acid
1,2-Pyrrolidinedicarboxylic acid, 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, 1-(1,1-dimethylethyl) ester, (2R,4R)-
应用领域
用途一
(2R,?4R)?-?1-?Boc-?N-?Fmoc-?4-?amino-?pyrrolidine-?2-?carboxylic Acid can be used as reactant/reagent in synthetic preparation of KMI-008 peptide derivatives and proline-based peptidomimetic analogs and determination of their activity as BACE1 inhibitors (β-secretase inhibitors). It can also be used as reagent/reactant for preparation of aminoproline residues for solid phase synthesis of integrin binding cyclic peptides by bromination, azidation and protection/deprotection protocol.