返回ChemicalBook首页>CAS数据库列表>1018675-35-8

1018675-35-8

中文名称 CS-2863
英文名称 CVT-12012
CAS 1018675-35-8
分子式 C21H21F3N4O3
分子量 434.41
MOL 文件 1018675-35-8.mol
更新日期 2024/10/12 11:25:53
1018675-35-8 结构式 1018675-35-8 结构式

基本信息

中文别名
化合物CVT-12012
英文别名
CS-2863
CVT-2012
CVT-12012
2-hydroxy-N-[2-[3-methyl-2-oxo-7-[[3-(trifluoromethyl)phenyl]methylamino]quinoxalin-1-yl]ethyl]acetamide
2-Hydroxy-N-[2-[3-methyl-2-oxo-7-[[[3-(trifluoromethyl)phenyl]methyl]amino]-1(2H)-quinoxalinyl]ethyl]acetamide
Acetamide, 2-hydroxy-N-[2-[3-methyl-2-oxo-7-[[[3-(trifluoromethyl)phenyl]methyl]amino]-1(2H)-quinoxalinyl]ethyl]-
2-Hydroxy-N-(2-(3-methyl-2-oxo-7-(((3-(trifluoromethyl)phenyl)methyl)amino)-1,2-dihydroquinoxalin-1-yl)ethyl)acetamide

物理化学性质

密度1.37±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml; Ethanol: 1 mg/ml
酸度系数(pKa)13.29±0.10(Predicted)
形态结晶固体
颜色Light yellow to yellow

常见问题列表

生物活性
CVT-12012 是一种有效的、具有口服活性的硬脂酰-CoA 去饱和酶 (SCD) 的抑制剂,其对大鼠微粒体和人 HEPG2 的 IC50 值分别为 38 nM,6.1 nM。
靶点

IC50: 38 nM (rat microsomal), 6.1 nM (human HEPG2).

体外研究

CVT-12012 (Compound 5b) displays the highest potency in both the microsomal and the HEPG2 SCD assays (IC 50 38 nM and 6.1 nM, respectively) compared to the other methyl-substituted compounds.

体内研究

In a rat PK study, CVT-12012 demonstrates good oral bioavailability (78%). It appears that the oral absorption of CVT-12012 is not affected by a significant Pgp efflux, which is expected based on Caco-2 assay result. The plasma clearance of CVT-12012 is high (88 mL/min/kg) with elimination half-life of approximately 1 h.

"1018675-35-8" 相关产品信息