102271-49-8
中文名称
102271-49-8
英文名称
2(3H)-Furanone, 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]dihydro-, (E)-
CAS
102271-49-8
分子式
C19H26O3
分子量
302.41
MOL 文件
102271-49-8.mol
更新日期
2023/03/20 15:41:23
102271-49-8 结构式
基本信息
中文别名
化合物PGS-IN-1 英文别名
PGS-IN-1α-(3,5-di-tert-butyl-4-hydroxybenzylidene)-γ-butyrolactone
2(3H)-Furanone, 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]dihydro-, (E)-
2(3H)-Furanone, 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]dihydro-, (E)- (9CI)
物理化学性质
沸点429.1±45.0 °C(Predicted)
密度1.096±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)11.51±0.50(Predicted)
形态Solid
颜色White to off-white
102271-49-8价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-101587 | 102271-49-8 PGS-IN-1 | 102271-49-8 | 1mg | 1500元 |
| 2024/04/30 | HY-101587 | 102271-49-8 PGS-IN-1 | 102271-49-8 | 5mg | 3000元 |
| 2024/04/30 | HY-101587 | 102271-49-8 PGS-IN-1 | 102271-49-8 | 10mg | 4500元 |
常见问题列表
生物活性
PGS-IN-1是有效的前列腺素合成酶 (prostaglandin synthetase) 抑制剂，IC50 值为0.28 μM；也可抑制5-脂肪氧合酶 (5-lipoxygenase) 的活性，IC50 值为 1.05 μM。靶点
|
5-Lipoxygenase 1.05 μM (IC 50 ) |
体外研究
The synthesized α-benzulidene-γ-butyrolactones are pure isomers (either cis or trans ). PGS-IN-1 is the trans isomer. PGS-IN-1 exhibits potent antiinflammatrory and PGS inhibitory activity (IC 50 =0.28 μM). PGS-IN-1 also shows potent inhibitory activity against 5-lipoxygenase (IC 50 =1.05 μM).