102704-40-5
102704-40-5 结构式
基本信息
中文别名
化合物 T27405 英文别名
AZ4AZ 4
AZ-4
GAT-211
GAT211 >=98% (HPLC)
3-(2-nitro-1-phenylethyl)-2-phenyl-1H-indole
1H-Indole, 3-(2-nitro-1-phenylethyl)-2-phenyl-
物理化学性质
储存条件-20°C储存
溶解度DMF: 25 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 10 mg/ml; Ethanol: 5 mg/ml
形态结晶固体
颜色White to off-white
应用领域
用途一
GAT211, aslo known as AZ-4, is a small molecule CB1 positive allosteric modulator. GAT211 suppresses allodynia and produces synergistic antiallodynic effects with fatty acid amide hydrolase and monoacylglycerol lipase inhibitors in paclitaxel-treated mice. Positive allosteric modulation of CB1-receptor signaling with GAT211shows promise as a safe and effective analgesic strategy that lacks tolerance, dependence, and abuse liability.