103213-49-6
中文名称
血纤维蛋白肽B
英文名称
GLU-GLY-VAL-ASN-ASP-ASN-GLU-GLU-GLY-PHE-PHE-SER-ALA-ARG
CAS
103213-49-6
分子式
C66H95N19O26
分子量
1570.57
MOL 文件
103213-49-6.mol
更新日期
2024/07/07 16:58:02
![103213-49-6 结构式](/CAS/GIF/103213-49-6.gif)
基本信息
中文别名
纤维蛋白肽B[GLU1]-纤维蛋白肽B
[GLU1]-FIBRINOPEPTIDEB 人
人[GLU1] FIBRINOPEPTIDE B肽
英文别名
FGBFibrinogen beta chain
(GLU1)-FIBRINOPEPTIDE B
[GLU1]-FIBRINOPEPTIDE B HUMAN
Glu1]-Fibrinopeptide B human >=90% (HPLC)
Monoclonal Anti-FGB antibody produced in mouse
GLU-GLY-VAL-ASN-ASP-ASN-GLU-GLU-GLY-PHE-SER-ALA-ARG
GLU-GLY-VAL-ASN-ASP-ASN-GLU-GLU-GLY-PHE-PHE-SER-ALA-ARG
H-GLU-GLY-VAL-ASN-ASP-ASN-GLU-GLU-GLY-PHE-PHE-SER-ALA-ARG-OH
所属类别
生物:蛋白与多肽物理化学性质
密度1.56±0.1 g/cm3(Predicted)
储存条件-20°C
酸度系数(pKa)3.33±0.10(Predicted)
形态粉末
颜色White to off-white
水溶解性Soluble in water at 1mg/ml
常见问题列表
生物活性
[Glu1]-Fibrinopeptide B 衍生自纤维蛋白肽B氨基酸残基1-14。人纤维蛋白肽B(hFpB)是来自纤维蛋白原B β链的凝血酶衍生的蛋白水解裂解产物,可用于刺激中性粒细胞 (PMN),单核细胞和成纤维细胞。体外研究
hFpB causes directed cell migration of PMN and fibroblasts that is optimal at approximately 10 nM. hFpB causes a rapid, dose-dependent increase in PMN cytoskeletal associated actin, but unlike fMLP, hFpB does not cause PMN aggregation, release of lysosomal enzymes (lysozyme and beta-glucuronidase), or the production of superoxide anion. These results suggest that hFpB may have a role in recruiting PMN and fibroblasts at sites of fibrin deposition and turnover. The capacity of hFpB to cause PMN chemotaxis without causing concurrent release of lysosomal enzymes or the production of superoxide anion is further evidence for the complexity of PMN responses to chemotactic agents.