1041852-85-0
中文名称
CS-2850
英文名称
AZD7507
CAS
1041852-85-0
分子式
C23H27FN6O3
分子量
454.5
MOL 文件
1041852-85-0.mol
更新日期
2024/07/04 17:30:42
1041852-85-0 结构式
基本信息
中文别名
化合物CS-2850 英文别名
AZD7507CS-2850
AZD7507
AZD-7507
AZD 7507
1041852-85-0
4-(2-fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide
3-Cinnolinecarboxamide, 4-[(2-fluoro-4-methylphenyl)amino]-6-[4-(2-hydroxyethyl)-1-piperazinyl]-7-methoxy-
物理化学性质
沸点680.7±65.0 °C(Predicted)
密度1.346±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)14.47±0.30(Predicted)
形态Solid
颜色Light yellow to yellow
常见问题列表
生物活性
AZD7507 为一种有效的、可口服的 CSF-1R 抑制剂，具有抗肿瘤活性。靶点
CSF-1R
体外研究
AZD7507 (Compound 31) inhibits the proliferation of 3T3 cells engineered to express CSF-1R and stimulated with CSF-1 (IC 50 , 32 nM), shows inhibitory activity against hERG and NaV1.5, with IC 50 s of >30 and 26 μM.
体内研究
AZD7507 has good rat oral PK, with in vivo clearance of 7 mL/min/kg and 42% bioavailability. In the canine L-type Ca channel assay, the IC 50 is >20 μM. AZD7507 significantly decreases the number of CD68 + macrophages in mice, and also reduces the volume and mass in mice bearing CC-LP-1 and SNU-1079 cells, but not WITT-1 cells.