基本信息
中文别名
硝米芬 英文别名
CI628Nitromifen
Nitromifene
1-[2-[4-[α-(4-Methoxyphenyl)-β-nitrostyryl]phenoxy]ethyl]pyrrolidine
Pyrrolidine, 1-[2-[4-[1-(4-methoxyphenyl)-2-nitro-2-phenylethenyl]phenoxy]ethyl]-
常见问题列表
生物活性
Nitromifene 是一个雌激素受体 (ER) 拮抗剂。靶点
ER
体外研究
Nitromifene is an antagonist of estrogen receptor (ER). At 0.5 μM and 1.0 μM concentrations, Nitromifene inhibits MCF 7 cell proliferation to 70% of that in drug-free controls. At higher concentrations, Nitromifene is clearly more effective than other metabolites. Specifically bound estradiol is displaced from intact MCF 7 cells by Nitromifene. Nitromifene is an effective antagonist of the ability of calmodulin (CM) to activate cyclic nucleotide phosphodiesterase.