104557-24-6
中文名称
脱乙酰头孢匹林钠盐
英文名称
Desacetyl Cephapirin SodiuM Salt
CAS
104557-24-6
分子式
C15H14N3NaO5S2
分子量
403.409
MOL 文件
104557-24-6.mol
104557-24-6 结构式
基本信息
中文别名
脱乙酰头孢匹林钠盐DESACETYL CEPHAPIRIN SODIUM SALT[干冰运输]
(6R-反式)-3-(羟基甲基)-8-氧代-7-[[(4-吡啶基硫基)乙酰基]氨基]-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-羧酸单钠盐
英文别名
Desacetylcephapirin sodiumDeacetylcephapirin SodiuM Salt
Desacetyl Cephapirin SodiuM Salt
(6R,7R)-3-(HydroxyMethyl)-8-oxo-7-[[2-(4-pyridinylthio)acetyl]aMino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid SodiuM Salt
(6R-trans)-3-(HydroxyMethyl)-8-oxo-7-[[(4-pyridinylthio)acetyl]aMino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid SodiuM Salt
(6R-trans)-3-(Hydroxymethyl)-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid monosodium salt
物理化学性质
熔点>160°C (dec.)
储存条件-20°C Freezer, Under Inert Atmosphere
溶解度可溶于DMSO（轻微）、甲醇（轻微、加热）、水（轻微、加热）
形态固体
颜色淡黄色至棕色
稳定性吸湿性
常见问题列表
生物活性
Desacetylcephapirin sodium (Deacetylcephapirin sodium) 是 Cephapirin (HY-A0153A) 的一种活性代谢物。Desacetylcephapirin sodium 对金黄色葡萄球菌和凝固酶阴性葡萄球菌乳腺炎病原体有抗菌作用。靶点
antibacterial
体外研究
Desacetylcephapirin sodium exhibits inhibitory activity on
Streptococcus dysgalactiae
, with MIC
50
s both of 0.25 µg/mL for clinical and subclinical bacterial strain.
Desacetylcephapirin sodium exhibits inhibitory activity on coagulase-negative staphylococci mastitis pathogen, with MIC
50
s both of 0.12 µg/mL for clinical and subclinical bacterial strain.