104615-18-1
104615-18-1 结构式
基本信息
9-氯-2-(2-呋喃基) - [1,2,4]三唑并[1,5-C]喹唑啉-5-胺
CGS-15943A
CGS-15943 solid
CGS-15943 ADENOSINE A1 RECEPTOR
9-CHLORO-2-(2-FURYL)(1,2,4)TRIAZOLO(1,5-C)QUINAZOLIN-5-AMINE
9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine
9-Chloro-2-(furan-2-yl)[1,2,4]triazolo[1,5-c]quinazolin-5-amine
9-CHLORO-2-(2-FURANYL)-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE
[1,2,4]Triazolo[1,5-c]quinazolin-5-amine,9-chloro-2-(2-furanyl)-
9-Chloro-5,6-dihydro-2-(furan-2-yl)[1,2,4]triazolo[1,5-c]quinazolin-5-imine
物理化学性质
常见问题列表
|
p110γ 1.1 μM (IC 50 ) |
p110δ 8.47 μM (IC 50 ) |
adenosine A1 receptor 3.5 nM (Ki) |
adenosine A2A receptor 4.2 nM (Ki) |
adenosine A2B receptor 16 nM (Ki) |
adenosine A3 receptor 51 nM (Ki) |
CGS 15943 inhibits the kinase activity of the class IB PI3K isoform p110γ with an IC 50 of 1.1 μM and shows slight inhibition on p110δ with an IC 50 of 8.47 μM. CGS 15943 (0-20 μM; 72 hours) inhibits growth of HLF and SK-Hep-1 cells, as well as HepG2 and PLC-PRF-5 cells. CGS 15943 (0-20 μM; 24 hours) reduces the phosphorylation of Akt at its residues Ser473 and Thr308 in HLF and Sk-Hep-1 cells.
Cell Viability Assay
| Cell Line: | HLF, SK-Hep-1, HepG2 and PLC-PRF-5 cells |
| Concentration: | 0 μM; 1 μM; 5 μM; 10 μM; 20 μM |
| Incubation Time: | 24 hours |
| Result: | Inhibited growth of four distinct HCC cell lines. |
Western Blot Analysis
| Cell Line: | HLF and Sk-Hep-1 cells |
| Concentration: | 0 μM; 1 μM; 5 μM; 10 μM; 20 μM |
| Incubation Time: | 24 hours |
| Result: | Inhibited the PI3K/Akt pathway in HLF and Sk-Hep-1 cells |