1049741-03-8
中文名称
TNF-α inhibitor
英文名称
TNF-α inhibitor
CAS
1049741-03-8
分子式
C32H33ClF3N3O2
分子量
584.08
MOL 文件
1049741-03-8.mol
1049741-03-8 结构式
物理化学性质
储存条件4°C, away from moisture
溶解度DMSO : 11.36 mg/mL (18.31 mM; ultrasonic and warming and heat to 60°C)
形态白色粉末状固体。
颜色White to off-white
常见问题列表
生物活性
SPD304 dihydrochloride 是肿瘤坏死因子 α (TNF-α) 的选择性抑制剂，能够促进肿瘤坏死因子三聚体的分离，从而阻断其与受体间的相互作用。SPD304 体外抑制肿瘤坏死因子 α 和受体 1 间结合的 IC50 值为 22 µM。靶点
IC50: 22 µM (TNFα).
体外研究
SPD304 (2 μM) significantly rescues the survivability of aHSCs, reduces the production of lipid hydroxides, and increased intracellular GSH. The co-treatment of GA (75 μM) and SPD304 (2 μM), down-regulate TRADD almost 2-fold (w/o inhibitor vs. w/ inhibitor) and p−RIP3 1.4−fold compared to GA alone, and promotes caspase 8 activation.
体内研究
SPD304 cannot be used in vivo due to its high toxicity.