106362-32-7
中文名称
106362-32-7
英文名称
ALA-SER-THR-THR-THR-ASN-TYR-THR ACETATE
CAS
106362-32-7
分子式
C35H55N9O16
分子量
857.86
MOL 文件
106362-32-7.mol
更新日期
2025/02/07 21:54:44
106362-32-7 结构式
基本信息
中文别名
肽TPEPTIDE T
ASTTTNYT
多肽T H-ALA-SER-THR-THR-THR-ASN-TYR-THR-OH
英文别名
ALA-SER-THR-THR-THR-ASN-TYR-THR ACETATEAla-Ser-Thr-Thr-Thr-Asn-Tyr-Thr acetate salt
L-Threonine, L-alanyl-L-seryl-L-threonyl-L-threonyl-L-threonyl-L-asparaginyl-L-tyrosyl-
L-Threonine, N-(N-(N2-(N-(N-(N-(N-L-alanyl-L-seryl)-L-thronyl)-L-threonyl)-L-threonyl)-L-asparaginyl)-L-tyrosyl)-
物理化学性质
沸点1499.5±65.0 °C(Predicted)
密度1.432±0.06 g/cm3(Predicted)
储存条件-20°C
溶解度Soluble in DMSO
酸度系数(pKa)3.21±0.10(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
Peptide T是源自HIV-1 gp120的V2区的八肽。 Peptide T是 CD4 受体的配体，可阻止 HIV 与CD4受体结合。靶点
CD4, HIV
体外研究
Peptide T acts to block viral entry as it inhibits in the MAGI cell assay and blocks infection in the luciferase reporter assay using HIV virions pseudotyped with ADA envelope. Peptide T selectively inhibits HIV replication using chemokine receptor CCR5 compared to CXC4. Peptide T at 10 -8 M induces IL-10 production by the human Th2 cell line and PBMC. Also peptide T at 10 -9 M concentration significantly inhibits IFN-g production by PBMC.
体内研究
Peptide T is administered subcutaneously at different doses and phases of the experimental autoimmune encephalomyelitis (EAE) disease, but Peptide T neither prevents nor ameliorates EAE.