106577-39-3
中文名称
黑海常春藤苷A1
英文名称
Hederacolchiside A1
CAS
106577-39-3
分子式
C47H76O16
分子量
897.1
MOL 文件
106577-39-3.mol
更新日期
2024/02/02 15:50:15
106577-39-3 结构式
基本信息
中文别名
黑海常春藤苷A1黑海常春藤皂苷A1
竹节香附皂苷R13
革叶常春藤皂苷A1
HEDERACOLCHISIDE A1(标准品)
齐墩果酸-3-O-Α-L鼠李吡喃糖基-(1→2)[Β-D-葡萄吡喃糖基-(1→4)] -Α-L-吡喃阿拉伯糖苷
齐墩果酸-3-O-Β-D-吡喃鼠李糖基-(1→2)-[Β-D-吡喃葡萄糖基-(1→4)]-Α-L-吡喃阿拉伯糖苷
英文别名
Raddeanoside R13Hederacolchiside A1
HEDERACOLCHISIDE A1
Hederacolchiside A1 USP/EP/BP
Oleanolic acid-3-O-β-D-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)-]-α-L-arabinopyranoside,Hederacolchiside A1
Olean-12-en-28-oicacid, 3-[(O-6-deoxy-a-L-mannopyranosyl-(12)-O-[b-D-glucopyranosyl-(14)]-a-L-arabinopyranosyl)oxy]-, (3b)-
Olean-12-en-28-oic acid, 3-[(O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosyl)oxy]-, (3β)-
所属类别
生物化工:植物提取物物理化学性质
熔点253-255℃ (methanol , water )
沸点967.2±65.0 °C(Predicted)
密度1.36±0.1 g/cm3 (20 ºC 760 Torr)
储存条件4°C, protect from light
溶解度溶于二甲基亚砜
酸度系数(pKa)4?+-.0.70(Predicted)
形态Solid
颜色White to off-white
常见问题列表
生物活性
Hederacolchiside A1 是从白头翁中分离的,通过调节 PI3K/Akt/mTOR 信号通路诱导凋亡,从而抑制肿瘤细胞的增殖。Hederacolchiside A1 具有抗血吸虫病活性,影响体内和体外的寄生虫生存力。靶点
PI3K
|
Akt
|
mTOR
|
体外研究
Hederacolchiside A1 reduces the mitochondrial membrane potential and Bcl-2 protein levels, whereas cleaved caspase-3 was higher.
Hederacolchiside A1 effectively inhibits the phosphorylations of phosphatidylinositol 3 kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) .
体内研究
hederacolchiside A1 (3.0, 4.5, and 6.0 mg/kg, ip) can significantly inhibit the weight of tumor in an H22 xenograft model.
Hederacolchiside A1 (3.25, 7.5, and 15.0 mg/kg, ig) can significantly inhibit the weight of tumor in nude mice xenograft tumor models using human breast carcinoma MCF-7 cells.