107220-28-0
中文名称
((+/-)-顺式-2-甲基螺[1,3-氧硫杂环戊烷-5,3'-奎宁环]盐酸半水合物
英文名称
Cevimeline Hydrochloride Salt
CAS
107220-28-0
分子式
C10H18ClNOS
分子量
235.774
MOL 文件
107220-28-0.mol
更新日期
2024/08/15 09:08:23
107220-28-0 结构式
基本信息
中文别名
西维美林-D4盐酸盐盐 英文别名
SNK 508Fks 508
Snd 5008
Saligren
CeviMelin
rac-Cevimeline HCl
AF-102B hydrochloride
SNI-2011 hydrochloride
Cevimelin Hydrochloride
CEVIMELINE, HYDROCHLORIDE SALT
所属类别
生物化工：激动剂抑制剂物理化学性质
熔点195-197?C
储存条件Inert atmosphere,Store in freezer, under -20°C
溶解度Water:50.0(Max Conc. mg/mL);212.07(Max Conc. mM)
形态结晶固体
颜色White to off-white
稳定性吸湿性
安全数据
警示词危险
危险性描述H301
毒性mouse,LD50,intravenous,33mg/kg (33mg/kg),United States Patent Document. Vol. #4855290,
常见问题列表
生物活性
Cevimeline hydrochloride (AF102B hydrochloride) 是一种乙酰胆碱的奎尼丁衍生物，也是一种选择性的和口服活性的毒蕈碱型 M1 和 M3 受体激动剂。Cevimeline hydrochloride 可刺激唾液腺分泌，并可用作口干症的一种催涎剂。Cevimeline hydrochloride 可穿过血脑屏障。靶点
Muscarinic M1 and M3 receptor
体外研究
In digested parotid cells, Cevimeline (0.1-100 μM) increases the intracellular Ca 2+ concentration.
体内研究
Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg.
| Animal Model: | Male Wistar rats (8-week-old) injected with angiotensin-II |
| Dosage: | 0.008 mg/kg, 0.016 mg/kg |
| Administration: | Intraperitoneal injection |
| Result: | Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. |