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107793-72-6

中文名称 碘昔兰
英文名称 IOXILAN (400 MG)
CAS 107793-72-6
分子式 C18H24I3N3O8
分子量 791.11
MOL 文件 107793-72-6.mol
更新日期 2024/03/22 17:31:03
107793-72-6 结构式 107793-72-6 结构式

基本信息

中文别名
碘昔兰
碘昔兰 USP标准品
英文别名
Ioxitol
Oxilan 300
IOXILAN (400 MG)
5-[Acetyl(2,3-dihydroxypropyl)aMino]-N1-(2,3-dihydroxypropyl)-N3-(2-hydroxyethyl)-2,4,6-triiodo-1,3-benzenedicarboxaMide
1,3-Benzenedicarboxamide, 5-[acetyl(2,3-dihydroxypropyl)amino]-N-(2,3-dihydroxypropyl)-N'-(2-hydroxyethyl)-2,4,6-triiodo-
1,3-Benzenedicarboxamide, 5-[acetyl(2,3-dihydroxypropyl)amino]-N1-(2,3-dihydroxypropyl)-N3-(2-hydroxyethyl)-2,4,6-triiodo-
5-[acetyl(2,3-dihydroxypropyl)amino]-3-N-(2,3-dihydroxypropyl)-1-N-(2-hydroxyethyl)-2,4,6-triiodobenzene-1,3-dicarboxamide

物理化学性质

沸点827.8±65.0 °C(Predicted)
密度2.205±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO: ≥ 250 mg/mL (316.01 mM)
酸度系数(pKa)11.47±0.46(Predicted)
形态Solid
颜色White to off-white

安全数据

海关编码2924296000

常见问题列表

生物活性
Ioxilan 是一种低渗,非离子和三碘化的诊断造影剂。Ioxilan 还是 X 射线造影剂,用于排泄性尿路造影和头部和身体的造影剂增强计算机断层扫描 (CECT) 成像。血管内注射使造影剂流动路径中的血管变得不透明,从而可以对人体内部结构进行射线照相可视化,直到发生明显的血液稀释为止。
体外研究

As a low-osmolar nonionic monomer, Ioxilan increases the safety and tolerance of X-ray contrast agents. The development of Ioxilan is based on the introduction of a double methylene as a hydrophobic region and masking it with a hydrophilic hydroxyl group could lower the osmolality without adversely affecting the biological tolerance.

体内研究

Rapid intravenous injection of water-soluble X-ray contrast agents (Ioxilan) can be performed with dynamic computed tomography to improve the detectability of liver lesions. When injected intravenously, water-soluble, intravenous X-ray contrast agents are largely distributed in the extracellular fluid space and excreted unchanged by the kidneys. Contrast enhancement of a region of interest depends on the route of administration, delivery of the agent to the area by blood flow, and the final iodine concentration in the region.

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