107889-32-7
107889-32-7 结构式
基本信息
中文别名
化合物 T15825 英文别名
LY 1780025-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]thiazolidin-4-one
4-Thiazolidinone, 5-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-
物理化学性质
沸点489.9±45.0 °C(Predicted)
密度1.139±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)11.15±0.50(Predicted)
常见问题列表
生物活性
LY 178002 是一种有效的 5-lipoxygenase (5-LPO) ，phospholipase A2 抑制剂，对 5-lipoxygenase 的 IC50 值为 0.6 μM，能够抑制人多形核白细胞产生 LTB4，同时可相对较弱地抑制 cyclooxygenase 的活性。靶点
|
5-LPO 0.6 μM (IC 50 ) |
PLA2 6.3 μM (IC 50 ) |
FCO 4.2 μM (IC 50 ) |
Cyclooxygenase
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体外研究
LY178002 inhibits the generation of LTB4, PLA2 and FCO with IC 50 s of 0.1, 6.3 and 4.2 μM .
体内研究
LY 178002 (50 mg/kg) inhibits soft tissue swelling in the uninjected paw by 81%, and inhibits bone damage in rats. The minimum effective dose for LY178002 is 10 mg/kg p.o. In the established FCA model LY178002 at 50 mg/kg p.o. inhibits the uninjected paw swelling by 75%.