108237-91-8
中文名称
108237-91-8
英文名称
4-bromo-phenyl-(4-phenyl-thiazol-2-yl)-amine
CAS
108237-91-8
分子式
C15H11BrN2S
分子量
331.23
MOL 文件
108237-91-8.mol
更新日期
2024/06/25 17:15:56
108237-91-8 结构式
基本信息
中文别名
化合物RCGD423N-(4-溴苯基)-4-苯基噻唑-2-胺
英文别名
RCGD423RCGD 432
2-Thiazolamine, N-(4-bromophenyl)-4-phenyl-
4-bromo-phenyl-(4-phenyl-thiazol-2-yl)-amine
物理化学性质
储存条件Keep in dark place,Inert atmosphere,2-8°C
储存条件under inert gas (nitrogen or Argon) at 2–8 °C
溶解度DMSO:34.0(Max Conc. mg/mL);102.6(Max Conc. mM)
Ethanol:34.0(Max Conc. mg/mL);102.6(Max Conc. mM)
Ethanol:34.0(Max Conc. mg/mL);102.6(Max Conc. mM)
形态固体
颜色Light yellow to yellow
108237-91-8价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-114775 | 108237-91-8 RCGD423 | 108237-91-8 | 5mg | 720元 |
| 2024/08/19 | HY-114775 | 108237-91-8 RCGD423 | 108237-91-8 | 10mM * 1mLin DMSO | 792元 |
| 2024/08/19 | HY-114775 | 108237-91-8 RCGD423 | 108237-91-8 | 10mg | 1100元 |
常见问题列表
生物活性
RCGD-423 是 Glycoprotein 130 (gp130, IL6ST, IL6-beta, CD130) 信号调节剂，可调节软骨生长和分化。靶点
|
IL6-beta
|
体外研究
RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.
体内研究
RCGD423 greatly reduces chondrocyte hypertrophy, loss and degeneration while increasing chondrocyte proliferation beyond that observed in response to injury in a rat partial meniscectomy model. Moreover, RCGD 423 improves cartilage healing in a rat full-thickness osteochondral defect model, increasing proliferation of mesenchymal cells in the defect and also inhibiting breakdown of cartilage matrix in de novo generated cartilage.