108477-18-5
中文名称
108477-18-5
英文名称
4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide
CAS
108477-18-5
分子式
C19H14N2O7S
分子量
414.39
MOL 文件
108477-18-5.mol
108477-18-5 结构式
基本信息
中文别名
半胱天冬酶和细胞凋亡激活剂(UBIQUITIN ISOPEPTIDASE INHIBITOR I, G5) 英文别名
NSC-144303Ubiquitin Isopeptidase-IN-G5
Ubiquitin Isopeptidase Inhibitor I
G5, Ubiquitin Isopeptidase Inhibitor I
Ubiquitin Isopeptidase Inhibitor I, G5
Ubiquitin Isopeptidase Inhibitor I, G5 (NSC144303)
4H-Thiopyran-4-one,tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-1,1-dioxide
物理化学性质
熔点233.5-234.5 °C
沸点693.0±55.0 °C(Predicted)
密度1.541±0.06 g/cm3(Predicted)
储存条件Store at -20°C,unstable in solution, ready to use.
溶解度≤15mg/ml in DMSO;1mg/ml in dimethyl formamide
形态结晶固体
颜色Light yellow to yellow
108477-18-5价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/08/19 | HY-100738 | 108477-18-5 Ubiquitin Isopeptidase Inhibitor I, G5 | 108477-18-5 | 5mg | 770元 |
| 2024/08/19 | HY-100738 | 108477-18-5 Ubiquitin Isopeptidase Inhibitor I, G5 | 108477-18-5 | 10mg | 1330元 |
| 2024/08/19 | HY-100738 | 108477-18-5 Ubiquitin Isopeptidase Inhibitor I, G5 | 108477-18-5 | 25mg | 2660元 |
常见问题列表
生物活性
Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303)是凋亡不依赖的半胱天冬酶和细胞凋亡的激活剂，对E1A和E1A/C9DN细胞的IC50值分别为1.76和1.6 μM。靶点
IC50: 1.76 μM (E1A cells), 1.6 μM (E1A/C9DN cells)
体外研究
G5 is capable of activating an apoptosome-independent apoptotic pathway. It targets the ubiquitinproteasome system by inhibiting the ubiquitin isopeptidases. G5 induces a rather unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with upregulation of the BH3-only protein Noxa, stabilization of the inhibitor of apoptosis antagonist Smac, but also the involvement of the death receptor pathway. G5 is a potent apoptotic inducer showing IC 50 s of 1.76 and 1.6 μM in E1A and E1A/C9DN cells, respectively.