1104546-89-5
中文名称
4-((1-甲基-1H-吡咯-2-基)亚甲基)异喹啉-1,3(2H,4H)-二酮
英文名称
4-[(1-Methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinolinedione
CAS
1104546-89-5
分子式
C15H12N2O2
分子量
252.27
MOL 文件
1104546-89-5.mol
更新日期
2024/09/03 14:18:05
1104546-89-5 结构式
基本信息
中文别名
化合物BYK2041654-((1-甲基-1H-吡咯-2-基)亚甲基)异喹啉-1,3(2H,4H)-二酮
英文别名
RT-017290BYK 204165
PARP Inhibitor XIV
BYK204165 >=98% (HPLC)
4-(1-methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinolin-1,3-dione
4-(1-Methyl-1H-pyrrol-2-ylmethylene)-4H-isoquinoline-1,3-dione
4-[(1-Methyl-1H-pyrrol-2-yl)methylene]-1,3(2H,4H)-isoquinolinedione
1,3(2H,4H)-Isoquinolinedione, 4-[(1-methyl-1H-pyrrol-2-yl)methylene]-
所属类别
生物化工：抑制剂物理化学性质
沸点492.5±45.0 °C(Predicted)
密度1.27±0.1 g/cm3(Predicted)
储存条件2-8°C
溶解度二甲基亚砜：>20mg/mL
酸度系数(pKa)9.30±0.20(Predicted)
形态粉末
颜色黄色
常见问题列表
生物活性
BYK204165 是一种有效的 poly(ADP-ribose) polymerase (PARP) 的选择性抑制剂。BYK204165 可抑制无细胞重组的人类PARP-1 (hPARP-1)对应的pIC50值和pKi值分别为7.35和7.05，对小鼠PARP-2 (mPARP-2)的pIC50值为5.38。靶点
| Target | Value |
|
hPARP-1
(Cell-free assay) | 7.35(pIC50) |
|
hPARP-1
(Cell-free assay) | 7.05(pKi) |
|
mPARP-2
(Cell-free assay) | 5.38(pIC50) |
体外研究
In kinetic experiments with human PARP-1, BYK204165 exhibits potent and competitive inhibition of enzyme activity, yielding a pK
i
value of 7.05.
BYK204165 exhibits low potency of PARP inhibition in C4I cells (pIC
50
of 5.75).
体内研究
BYK204165 is not investigated in vivo because of its short half-time (t 1/2 ) of 23 min measured at rat microsomes in vitro.