11076-29-2

中文名称 Streptomyces pepsin inhibitor

CAS 11076-29-2

分子式 C31H57N5O9

分子量 643.81

MOL 文件 11076-29-2.mol

11076-29-2 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

乙酰胃泌素

英文别名

Pepsidin c
Pepstatin AC
Streptomyces pepsin inhibitor
acetyl pepstatin|acetyl-pepstatin
N-Ac-L-Val-L-Val-Sta-L-Ala-Sta-OH
Ac-Val-val-4-amino-3-hydroxy-6-me-heptanoyl-Ala-4-amino-3-hydroxyl-6-me-heptanoic acid
Acetylvalylvalyl-4-amino-3-hydroxy-6-methylheptanoylalanyl-4-amino-3-hydroxyl-6-methylheptanoic acid
N-Acetyl-L-Val-L-Val-[(3S,4S)-4-amino*-3-hydroxy-6-methylheptanoyl]-L-Ala-[(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl]NH2
L-Alaninamide, N-acetyl-L-valyl-L-valyl-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl-N-[(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl]-
L-Alaninamide, N-acetyl-L-valyl-L-valyl-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl-N-[(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl]- (9ci)

物理化学性质

熔点223-225 °C

沸点992.8±65.0 °C(Predicted)

密度1.142±0.06 g/cm3(Predicted)

酸度系数(pKa)4.17±0.10(Predicted)

常见问题列表

生物活性

Acetyl-pepstatin 是一种强效的异嗜性鼠白血病病毒相关病毒 (XMRV) 蛋白酶 (PRs) 和 HIV-1 PR 抑制剂，Ki 分别为 712 和 13 nM。

体外研究

Inhibition of the XMRV PR-mediated cleavage of a recombinant murine leukemia virus (MLV) Gag fragment by Acetyl-pepstatin (3.1 μM).