1115-65-7
1115-65-7 结构式
基本信息
L-半胱氨酸亚磺酸
3-亚磺基-L-丙氨酸
Α-氨基-Β-亚磺基丙酸
3-sulphino-L-alanine
L-CYSTEINESULFINIC ACID
L-cysteine sulphinic acid
CYSTEINE(L) SULFINIC ACID
2-amino-3-sulfino-propanoic acid
L-CYSTEINESULFINIC ACID 1-HYDRATE
物理化学性质
常见问题列表
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mGluR1 3.92 (pEC 50 ) |
mGluR2 3.9 (pEC 50 ) |
mGluR4 2.7 (pEC 50 ) |
mGluR5 4.6 (pEC 50 ) |
mGluR6 4.0 (pEC 50 ) |
mGluR8 3.94 (pEC 50 ) |
Human Endogenous Metabolite
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L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC 50 of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increases in cell firing.