111757-17-6

中文名称 N-(2-pyridone-6-yl)-N',N'-di-n-propylformamidine

英文名称 N-(2-pyridone-6-yl)-N',N'-di-n-propylformamidine

CAS 111757-17-6

分子式 C12H19N3O

分子量 221.3

MOL 文件 111757-17-6.mol

111757-17-6 结构式

基本信息应用领域

基本信息

中文别名

化合物 T26997

英文别名

CGP 28014
N-(2-pyridone-6-yl)-N',N'-di-n-propylformamidine
Methanimidamide, N'-(1,6-dihydro-6-oxo-2-pyridinyl)-N,N-dipropyl-

应用领域

用途一

CGP-28014 is a catechol-O-methyltransferase inhibitor potentially for the treatment of Parkinson's disease.Although CGP-28014 increases the renal excretion of both dopamine and dihydroxyphenylacetic acid (DOPAC) it does not affect renal sodium handling indicating a different mechanism of action. CGP-28014 significantly reduced the levels of homovanillic acid (HVA), but did not modify DA and 3,4-dihydroxyphenylacetic acid (DOPAC).