1125593-20-5
1125593-20-5 结构式
基本信息
1-[4-[[4-[[2-(异丙基磺酰基)苯基]氨基]-1H-吡咯并[2,3-B]吡啶-6-基]氨基]-3-甲氧基苯基]哌啶-4-醇
Mps1 inhibitor
Mps1 inhibitor 1
1-(4-(4-(2-(Isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl
1-(4-(4-(2-(isopropylsulfonyl)phenylamino)-1H-pyrrolo[2,3-b]pyridin-6-ylamino)-3-methoxyphenyl)piperidin-4-ol
1MPS1-IN-1
1-(4-(4-(2-(ISOPROPYLSULFONYL)PHENYLAMINO)-1H-PYRROLO[2,3-B]PYRIDIN-6-YLAMINO)-3-METHOXYPHENYL)PIPERIDIN-4-OL
4-Piperidinol, 1-[3-methoxy-4-[[4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]phenyl]-
物理化学性质
常见问题列表
|
Mps1 367 nM (IC 50 ) |
Mps1 27 nM (Kd) |
ALK 21 nM (Kd) |
LTK 29 nM (Kd) |
PYK2 280 nM (Kd) |
FAK 440 nM (Kd) |
IGF1R 750 nM (Kd) |
INSR 470 nM (Kd) |
CLK1 1900 nM (Kd) |
ERK2 2900 nM (Kd) |
INSRR 1200 nM (Kd) |
TNK1 2600 nM (Kd) |
TNK2 3100 nM (Kd) |
GAK 1100 nM (Kd) |
Mps1-IN-1 is a potent, selective and ATP-competitive Mps1 kinase inhibitor, with an IC 50 and a K d of 367 nM and 27 nM. Mps1-IN-1 also has high affinity for ALK, and LTK, with K d s of 21 and 39 nM, respectively, but shows little or no inhibition on other 352 member kinases. Mps1-IN-1 (5, 10 μM) induces bypass of a checkpoint-mediated mitotic arrest in U2OS cells. Mps1-IN-1 disrupts recruitment of Mad2 to kinetochores, and reduces the phosphorylation status of Aurora B at threonine-232 (Thr232). Mps1-IN-1 (10 µM) shows no effect on centrosome duplication. In addition, Mps1-IN-1 (5-10 µM) suppresses the proliferative capacity of HCT116.