112898-15-4

中文名称 2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C)

英文名称 2'- AND 3'-O-(4-BENZOYLBENZOYL)-ADENOSINE 5'-TRIPHOSPHATE TRIETHYLAMMONIUM SALT

CAS 112898-15-4

分子式 C30H39N6O15P3

分子量 816.58

MOL 文件 112898-15-4.mol

更新日期 2024/04/17 23:13:11

112898-15-4 结构式

基本信息物理化学性质安全数据图谱信息 2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C)价格(试剂级) 常见问题列表

基本信息

中文别名

2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐
2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C)
腺苷 5'-(三磷酸四氢酯) 3'-(4-苯甲酰基苯甲酸酯) 三乙胺盐

英文别名

benzoylbenzoyl-atp
BzATP triethylammonium salt
Benzoylbenzoyl-ATP, Bz-ATP
2'(3')-o-(4-benzoylbenzoyl)adeno
BENZOYLBENZOIC ADENOSINE 5'-TRIPHOSPHATE
2'-3'-O-(4-benzoylbenzoyl)adenosine*5'-triphospha
2'-3'-O-(4-BENZOYLBENZOYL)ADENOSINE5'-TR IPHOSPHATE
benzoylbenzoyl-ATP triethylammonium salt, mixed isomers
2'(3')-o-(4-benzoylbenzoyl)adenosine 5'-triphosphate triethylammonium salt
2'(3')-O-(4-Benzoylbenzoyl)adenosine-5'-triphosphatetri(triethylammonium)salt

物理化学性质

储存条件-20°C

溶解度≤14 mg/ml in DMSO

形态固体

颜色白色至灰白色

水溶解性Soluble in water (supplied pre-dissolved at a concentration of 5mM)

InChIKeyHVOVBTNCGADRTH-WBLDMZOZSA-N

安全数据

危险性符号(GHS)

GHS07

警示词警告

危险性描述H302-H315-H319-H335

防范说明P261-P280-P301+P312-P302+P352-P305+P351+P338

WGK Germany3

图谱信息

2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C)(112898-15-4)核磁图(¹HNMR)

2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C)价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-136254	2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C) BzATP triethylammonium salt	112898-15-4	5mg	1200元
2024/04/30	HY-136254	2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C) BzATP triethylammonium salt	112898-15-4	10mg	1900元
2024/04/30	HY-136254	2-3-(4-苯甲酰苯甲酰)腺苷 5-三磷酸三乙铵盐(-20°C) BzATP triethylammonium salt	112898-15-4	25mg	3900元

常见问题列表

生物活性

BzATP triethylammonium salt 是一种 P2X 受体激动剂，对 P2X1，P2X2，P2X3，P2X2/3，P2X4 和 P2X7 的 pEC50 分别为 8.74，5.26，7.10，7.50， 6.19，6.31 和 5.33。BzATP triethylammonium salt 对 P2X7 受体有效，对大鼠 P2X7 和小鼠 P2X7 的EC50 分别为 3.6 μM 和 285 μM。

靶点

pEC50: 8.74 (P2X1), 5.26 (P2X2), 7.10 (P2X3), 6.19 (P2X2/3), 6.31 (P2X4), 5.33 (P2X7)
EC50 3.6 μM (rat P2X7); 285 μM (mouse P2X7)

体外研究

BzATP (10-1000 μM; 24 h) promotes the proliferation and migration of U87 and U251 glioma cells.
P2X7R protein expression is induced by BzATP (100 μM; 6-48 h) in human glioma cells.

Cell Proliferation Assay

Cell Line:	U87 and U251 glioma cells
Concentration:	5, 10, 50, 100, 500 and 1000 μM
Incubation Time:	2, 6, 12, 24, 48 and 72 hours
Result:	The proliferation of U87 and U251 glioma cell lines was significantly increased in the presence of 10-1000 uM and 100-1000 μM, respectively. The peak of cell proliferation of both U87 and U251 cell lines was at 100 μM. The optimal incubation time is 24 hours in both U87 and U251 cells lines.

Western Blot Analysis

Cell Line:	U87 and U251 glioma cells
Concentration:	100 μM
Incubation Time:	6-48 hours
Result:	Induced the upregulation of P2X7R.

体内研究

BzATP (5 mg/kg) significantly promotes P2X7R expression in the intestines compared with intestines in the sham group and the control group after cecal ligation and puncture (CLP) induction.

Animal Model:	Male 2-month-old C57BL/6 mice (each weighing between 20 and 25 g)
Dosage:	5 mg/kg
Administration:	Injected through the intraperitoneal route
Result:	At 48 hours, mice in the treated group and control group exhibited mortalities of 91% and 86%, respectively.