1134188-71-8
中文名称
奥卡西平-D4
英文名称
OXCARBAZEPINE-D4
CAS
1134188-71-8
分子式
C15H8D4N2O2
分子量
256.29
MOL 文件
1134188-71-8.mol
更新日期
2024/08/26 09:59:17
1134188-71-8 结构式
基本信息
中文别名
奥卡西平-D4 英文别名
TRILEPTAL-D4OXCARBAZEPINE-D4
10,11-DIHYDRO-10-OXO-5H-DIBENZ[B,F]AZEPINE-5-CARBOXAMIDE-D4
1,2,3,4-tetradeuterio-5-oxo-6H-benzo[b][1]benzazepine-11-carboxamide
应用领域
用途一
Oxcarbazepine-d4 is intended for use as an internal standard for the quantification of oxcarbazepine by GC- or LC-MS. Oxcarbazepine is a prodrug form of the antiepileptic compound 10,11-dihydro-10-hydroxy carbamazepine . It inhibits high-frequency repetitive firing of rat spinal cord neurons when used at a concentration of 1 μM. Oxcarbazepine protects against electroshock-induced tonic hindlimb extension (ED50s = 10-20 mg/kg), as well as seizures induced by pentylenetetrazole (PTZ; ) or picrotoxin in rodents (ED50s = 23-30 and 150-250 mg/kg, respectively). Formulations containing oxcarbazepine have been used in the treatment of epileptic seizures.