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114899-80-8

中文名称 114899-80-8
英文名称 Ecteinascidin 770
CAS 114899-80-8
分子式 C40H42N4O10S
分子量 770.85
MOL 文件 114899-80-8.mol
更新日期 2024/11/18 16:17:56
114899-80-8 结构式 114899-80-8 结构式

基本信息

中文别名
U373MG细胞抑制剂(ECTEINASCIDIN 770)
英文别名
Et-770
Ecteinascidin 770
Ecteinascidine 770
Trabectedin Intermediates N-1
Spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinoline]-14-carbonitrile, 5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8-dihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-, (1'R,6R,6aR,7R,13S,14R,16R)-

物理化学性质

密度1.53±0.1 g/cm3(Predicted)
储存条件-20°C, protect from light
溶解度溶于二甲基亚砜
酸度系数(pKa)9.65±0.40(Predicted)
形态Solid
颜色White to off-white

常见问题列表

生物活性
Ecteinascidin 770 (ET-770)是具有抗癌活性的1,2,3,4-四氢异喹啉生物碱,抑制U373MG cells的IC50值为4.83 nM。
靶点

IC50: 4.83 nM (U373MG cell); 0.6 nM (HCT116 cell), 2.4 nM (QG56 cell), 0.81 nM (DU145)

体外研究

Ecteinascidin 770 induces apoptosis of U373MG cells. The IC 50 concentration of ecteinascidin 770 for killing U373MG glioblastoma cells in culture by using the MTT assay is 4.83 nM by a 72 hour-treatment. The IC 50 values against human cell lines HCT116, QG56, and DU145 are 0.6, 2.4, and 0.81 nM, respectively. ET-770 is shown to enhance anoikis response of human lung cancer H23 cells in a dose-dependent manner. Ecteinascidin 770 sensitizes the cells by activating the p53 protein, which in turn down-regulates anti-apoptotic myeloid cell leukemia sequence-1 (MCL1) and up-regulates BCL2-associated X protein (BAX) proteins. However, B-cell lymphoma-2 (BCL2) proteins are not significantly affected by Ecteinascidin 770. The anoikis sensitization of ET-770 is observed in H460 lung cancer cells.

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