1149348-10-6
中文名称
FGI-106
英文名称
FGI-106
CAS
1149348-10-6
分子式
C28H39ClN6
分子量
495.11
MOL 文件
1149348-10-6.mol
更新日期
2024/07/23 12:03:31
1149348-10-6 结构式
基本信息
中文别名
化合物 T11281L化合物FGI-106 TETRAHYDROCHLORIDE
英文别名
FGI-106 HClFGI-106 tetrahydrochloride
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常见问题列表
生物活性
FGI-106 tetrahydrochloride 是一种有效的广谱抑制剂，对多种病毒具有抑制活性。FGI-106 tetrahydrochloride 具有抗埃博拉病毒 (EBOV)，裂谷病毒 (Rift Valley virus) 和登革热病毒 (Dengue Fever virus) 的活性，其 EC50 分别为 100 nM，800 nM 和 400-900 nM。FGI-106 tetrahydrochloride 还分别以 EC50 值为 200 nM 和 150 nM 抑制非失血性发热病毒 HCV 和 HIV-1。靶点
EC50: 100 nM (Ebola virus), 800 nM (Rift Valley virus), 400-900 nM (Dengue Fever virus), 200 nM (HCV) and 150 nM (HIV-1)
体外研究
Treatment with 2 μM FGI-106 mediated a 4 log reduction in infectious viral titers relative to matched controls, with an EC
90
for inhibition of viral killing of host cells (Vero E6 cells) estimated to be 0.6 μM.
In cell-based assays, treatment with FGI-106 inhibits viral replication by divergent virus families, including positive and negative-strand RNA viruses.
体内研究
FGI-106 (0.1-5 mg/kg; intraperitoneal injection; treatments on days 2 and 5; C57BL/6 or BALB/c mice) treatment decreases mortality from Zaire EBOV in a dose-dependent manner.
| Animal Model: | Male or female C57BL/6 or BALB/c mice (6-10 weeks of age) injected with EBOV (Ebola virus) |
| Dosage: | 0.1 mg/kg, 0.5 mg/kg, 1 mg/kg, 2 mg/kg, 5 mg/kg |
| Administration: | Intraperitoneal injection; treatments on days 2 and 5 |
| Result: | Decreased mortality from Zaire EBOV in a dose-dependent manner. |