1158279-20-9
中文名称
无中文名称
英文名称
HLCL-61 (hydrochloride)
CAS
1158279-20-9
分子式
C23H25ClN2O
分子量
380.92
MOL 文件
1158279-20-9.mol
1158279-20-9 结构式
基本信息
中文别名
HLCL-61 盐酸盐PRMT5抑制剂(HLCL-61 HYDROCHLORIDE)
英文别名
CS-2798HLCL-61.HCl
HLCL61
HLCL 61
HLCL-61 (hydrochloride)
HLCL61
HLCL 61
HLCL 61 HYDROCHLORIDE
所属类别
生物化工：激动剂抑制剂物理化学性质
储存条件Inert atmosphere,Store in freezer, under -20°C
溶解度≥20.4 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
形态结晶固体
颜色White to off-white
HLCL-61 盐酸盐价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-100025A | 1-(9-乙基-9H-咔唑-3-基)-N-(2-甲氧基苄基)甲胺盐酸盐 HLCL-61 hydrochloride | 1158279-20-9 | 5mg | 500元 |
| 2024/04/30 | HY-100025A | 1-(9-乙基-9H-咔唑-3-基)-N-(2-甲氧基苄基)甲胺盐酸盐 HLCL-61 hydrochloride | 1158279-20-9 | 10mM * 1mLin DMSO | 550元 |
| 2024/04/30 | HY-100025A | 1-(9-乙基-9H-咔唑-3-基)-N-(2-甲氧基苄基)甲胺盐酸盐 HLCL-61 hydrochloride | 1158279-20-9 | 10mg | 750元 |
常见问题列表
生物活性
HLCL-61 hydrochloride 是首创的小分子蛋白精氨酸甲基转移酶 5 (PRMT5) 抑制剂。靶点
Protein arginine methyltransferase 5
体外研究
HLCL-61 hydrochloride (1-100 μM; 24-72 hours) reduces cells growth at dose-dependent manner with IC
50
s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively.
HLCL-61 hydrochloride shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, starting at 12 h post-treatment and persisting after 48 h.
Cell Viability Assay
| Cell Line: | MV4-11 cells, THP-1 cells, FLT3-WT blast (primary blasts from patients), FLT3-ITD blast (primary blasts from patients) |
| Concentration: | 1, 5, 10, 25, 50, 100 μM |
| Incubation Time: | 24, 48, 72 hours |
| Result: | Dose-dependent reduction in cell viability with IC 50 s of 14.12, 16.74, 6.3, 8.72 μM for MV4-11 cells, THP-1 cells, FLT3-WT blast, and FLT3-ITD blast, respectively. |