116289-53-3
116289-53-3 结构式
基本信息
中文别名
妥洛帕泛 英文别名
Tulopafant1H,3H-Pyrrolo[1,2-c]thiazole-7-carboxamide, N-(3-benzoylphenyl)-3-(3-pyridinyl)-, (+)-
物理化学性质
沸点613.3±55.0 °C(Predicted)
密度1.32±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度溶于二甲基亚砜
酸度系数(pKa)13.51±0.70(Predicted)
常见问题列表
生物活性
Tulopafant 是血小板激活因子 (PAF) 拮抗剂。体外研究
Preincubation of neutrophils with Tulopafant (RP 59227) results in a concentration-dependent decrease in chemiluminescence produced by PAF primed cells.
体内研究
Tulopafant (RP 59227) effectively reduces myocardial infarct size and reduces the incidence of ischemia and reperfusion-induced arrhythmias in barbital-anesthetized dogs.Histological examination reveals marked diminution of both interstitial hemorrhage and deposition of platelet and granulocytes in capillaries of cardiac xenografts when recipient animals are pretreated with Tulopafant.